Treatment of Comorbid Conditions



Michael R Hamblin, Ph.D.

Wellman Center for Photomedicine

Massachusetts General Hospital

Harvard Medical School


Dr. George Lindenfeld has concentrated his attention on neuro-scientific applications for post-traumatic stress disorder (PTSD), which has recently come into public and media prominence due to its high prevalence in military Veterans. Taking a look at emerging therapies, I can confidently predict that the 21st century will be remembered as the time when brain science truly came into its own.


Broadly speaking, the first half of the 20th century was the age of psychotherapy, psychoanalysis and other talking therapies. Following that, the second half of the 20th century was the age of pharmaceuticals and psychiatric drugs. Even today anti-depressants, anti-psychotics, anxiolytics and sleeping pills are some of the most oft-prescribed medications in the Western world.


One of the most important concepts that has arisen in this emerging field of neuroscience is called “synaptic plasticity.” In this sense, acoustical neuromodulation and photobiomodulation share a common mechanistic foundation resting on neuroplasticity. As I read about the applications of RESET Therapy to the PTSD comorbid conditions enumerated in this book, I was struck with an awareness of the inherent potential in each and every cell in our body to heal and restore itself.


As I read his material, it is clear that Dr. Lindenfeld has found that acoustical neuro-modulation interrupts the memory reconsolidation process within the retention network of the brain thereby permitting it to reset to pre-trauma levels. He proposes that when we combine the treatment he calls RESET Therapy with Photobiomodulation we emerge with a perfectly balanced, ‘peanut-butter and jelly sandwich.’ 


The concept here is that intervention with RESET blocks the insidious effects of unresolved trauma from perpetuating damage to the body as a whole. On the other hand, PBMT triggers: an increase in regional cerebral blood flow; improves brain oxygenation; increases ATP levels that are crucial for effective brain function. 


Apparently, one shared function of both the light that induces photobiomodulation, and the sound that returns the cell to its inherent growth potential, is their apparent ability to diminish the neuro-inflammation effect. This phenomenon is especially damaging to the brain if excessively prolonged. 


In the memorable phrase that formed the title of Dr. Lindenfeld’s previous book, “Brain on Fire”, it is clear that PTSD goes beyond simple “fear extinction” that has long been studied in animal models. I hope that Dr. Lindenfeld can continue to push the frontiers forward in PTSD therapy, and I personally wish him the best of luck.


Thank you, Dr. Lindenfeld


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